|本期目录/Table of Contents|

[1]张麟,郝坛义.靶向于胶原蛋白的血栓抑制剂LERNSTY开发[J].天津大学学报(自然科学版),2018,(04):401-405.[doi:10.11784/tdxbz201704012]
 Zhang Lin,Hao Tanyi.Development of Thrombus Inhibitor LERNSTY Targeted at Collagen[J].Journal of Tianjin University,2018,(04):401-405.[doi:10.11784/tdxbz201704012]
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靶向于胶原蛋白的血栓抑制剂LERNSTY开发()
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《天津大学学报(自然科学版)》[ISSN:0493-2137/CN:12-1127/N]

卷:
期数:
2018年04
页码:
401-405
栏目:
论文
出版日期:
2018-04-15

文章信息/Info

Title:
Development of Thrombus Inhibitor LERNSTY Targeted at Collagen
文章编号:
0493-2137(2018)04-0401-05
作者:
张麟 郝坛义
天津大学化工学院,天津 300350
Author(s):
Zhang Lin Hao Tanyi
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China
关键词:
动脉血栓 胶原蛋白 血栓抑制剂 水溶性
Keywords:
arterial thrombosis collagen thrombus inhibitor solubility
分类号:
TQ464.7
DOI:
10.11784/tdxbz201704012
文献标志码:
A
摘要:
通过荷电氨基酸残基替换LWWNSYY中的疏水性氨基酸残基W以优化其组成, 设计获得血栓抑制剂LERNSTY.研究发现, LERNSTY溶解度好, 能够有效结合胶原蛋白, Kd为(1.647±0.303)μmol/L, 有效半抑制浓度(IC50)为(2.73±0.48)μg/mL, 优于LWWNSYY.因此, 通过荷电氨基酸的引入优化获得有效的血栓抑制剂LERNSTY, 将促进疗效显著而副作用小的抗血栓药物开发.
Abstract:
A thrombus inhibitor LERNSTY was designed based on the optimization of LWWNSYY by replacing the hydrophobic amino acid residue W with charged amino acid residues. LERNSTY was found to have good solubility. It could effectively bind with collagen with a Kd of (1.647±0.303) μmol/L. An effective half inhibitory concentration (IC50) of (2.73±0.48) μg/mL was obtained, which was better than that of LWWNSYY. Therefore, an effective thrombus inhibitor LERNSTY was obtained through the introduction of charged amino acid residues, which would facilitate the development of curative antithrombotic drugs with fewer side effects.

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相似文献/References:

[1]张麟,孙娜.血栓纳米抑制剂m5k-BAD-L的构建及其性能研究[J].天津大学学报(自然科学版),2017,(05):477.[doi:10.11784/tdxbz201603079]
 Zhang Lin,Sun Na.Design and Characterization of Antithrombotic Nanoconjugate―m5k-BAD-L[J].Journal of Tianjin University,2017,(04):477.[doi:10.11784/tdxbz201603079]

备注/Memo

备注/Memo:
收稿日期: 2017-04-05; 修回日期: 2017-05-05.
作者简介: 张麟(1981—), 男, 博士, 教授.
通讯作者: 张麟, linzhang@tju.edu.cn.
网络出版时间: 2017-05-17.网络出版地址: http://kns.cnki.net/kcms/detail/12.1127.N.20170517.1127.004.html.
基金项目: 国家自然科学基金资助项目(91534119); 天津大学自主创新基金资助项目.
Supported by the National Natural Science Foundation of China(No.,91534119)and the Innovation Foundation of Tianjin University.
更新日期/Last Update: 2018-04-10