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 Zhang Lin,Hao Tanyi.Development of Thrombus Inhibitor LERNSTY Targeted at Collagen[J].Journal of Tianjin University,2018,(04):401-405.[doi:10.11784/tdxbz201704012]



[1] Makris M, Calizzani G, Fischer K, et al. EUHASS:The European haemophilia safety surveillance system[J]. Thrombosis Research, 2011, 127(S2):22-25.
[2] Stoll G, Kleinschnitz C, Nieswandt B. Molecular mechanisms of thrombus formation in ischemic stroke:Novel insights and targets for treatment[J]. Blood, 2008, 112(9):3555-3562.
[3] Furie B, Furie B C. Mechanisms of thrombus formation[J]. New England Journal of Medicine, 2008, 359(9):938-949.
[4] Liu J. Research and development of biotechnology and drugs[J]. Journal of University of Science & Technology of China, 2008, 38(8):905-908.
[5] Stegner D, Nieswandt B. Platelet receptor signaling in thrombus formation[J]. J Mol Med(Berl), 2011, 89(2):109-121.
[6] Welsh R C, Roe M T, Steg P G, et al. A critical re-appraisal of aspirin for secondary prevention in patients with ischemic heart disease[J]. American Heart Journal, 2016, 181:92-100.
[7] Zhang L, Sun Y. Biomimetic design of platelet adhesion inhibitors to block integrin alpha2beta1-collagen interactions:I. Construction of an affinity binding model [J]. Langmuir, 2014, 30(16):4725-4733.
[8] Zhang L, Zhang C, Sun Y. Biomimetic design of platelet adhesion inhibitors to block integrin alpha2beta1-collagen interactions:II. Inhibitor library, screening, and experimental validation[J]. Langmuir, 2014, 30(16):4734-4742.
[9] Zhang Chao, Zhang Lin, Zhang Youcai, et al. Development of antithrombotic nanoconjugate blocking integrin alpha2beta1-collagen interactions[J]. Sci Rep, 2016, 6:26292.
[10] Lipinski C A. Drug-like properties and the causes of poor solubility and poor permeability[J]. Journal of Pharmacological & Toxicological Methods, 2000, 44(1):235-249.
[11] Serajuddin A T. Salt formation to improve drug solubility [J]. Advanced Drug Delivery Reviews, 2007, 59(7):603-616.
[12] Loftsson T. Aqueous solubility and true solutions[J]. Pharmazie, 2010, 65(6):404-407.
[13] 邓联东, 董岸杰, 张跃庭, 等. 负载紫杉醇的两亲性共聚物纳米粒[J]. 天津大学学报, 2004, 37(1):15-
Deng Liandong, Dong Anjie, Zhang Yueting, et al. Paclitaxel-loaded amphiphilic copolymer nanoparticles[J] Journal of Tianjin University, 2004, 37(1):15-18(in Chinese).
[14] Deglau T E, Maul T M, Villanueva F S, et al. In vivo PEG modification of vascular surfaces for targeted delivery[J]. J Vasc Surg, 2012, 55(4):1087-1095.
[15] 张麟, 孙娜. 血栓纳米抑制剂m5k-BAD-L的构建及其性能研究[J]. 天津大学学报:自然科学与工程技术版, 2017, 50(5):477-482.
Zhang Lin, Sun Na. Design and characerization of antithrombotic nanoconjugate―m5k-BAD-L[J] Journal of Tianjin University:Science and Technology, 2017, 50(5):477-482(in Chinese).
[16] Emsley J, Knight C G, Farndale R W, et al. Structural basis of collagen recognition by integrin α2β1[J]. Cell, 2000, 101(1):47-56.
[17] Calderwood D A, Tuckwell D S, Eble J, et al. The integrin alpha1 A-domain is a ligand binding site for collagens and laminin[J]. Journal of Biological Chemistry, 1997, 272(19):12311-12317.
[18] Jung S M, Moroi M. Platelets interact with soluble and insoluble collagens through characteristically different reactions[J]. Journal of Biological Chemistry, 1998, 273(24):14827-14837.
[19] Cruz M A, Chen J, Whitelock J L, et al. The platelet glycoprotein Ib-von Willebrand factor interaction activates the collagen receptor alpha2beta1 to bind collagen:Activation-dependent conformational change of the alpha2-I domain[J]. Blood, 2005, 105(5):1986-1991.
[20] Ivaska J, Kapyla J, Pentikainen O, et al. A peptide inhibiting the collagen binding function of integrin 2I domain[J]. Journal of Biological Chemistry, 1999, 274(6):3513-3521.
[21] Miller M W, Basra S, Kulp D W, et al. Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism[J]. Proc Natl Acad Sci, 2009, 106(3):719-724.
[22] Trott O, Olson A J. AutoDock Vina:Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading [J]. Journal of Computational Chemistry, 2010, 31(2):455-461.


 Zhang Lin,Sun Na.Design and Characterization of Antithrombotic Nanoconjugate―m5k-BAD-L[J].Journal of Tianjin University,2017,(04):477.[doi:10.11784/tdxbz201603079]


收稿日期: 2017-04-05; 修回日期: 2017-05-05.
作者简介: 张麟(1981—), 男, 博士, 教授.
通讯作者: 张麟, linzhang@tju.edu.cn.
网络出版时间: 2017-05-17.网络出版地址: http://kns.cnki.net/kcms/detail/12.1127.N.20170517.1127.004.html.
基金项目: 国家自然科学基金资助项目(91534119); 天津大学自主创新基金资助项目.
Supported by the National Natural Science Foundation of China(No.,91534119)and the Innovation Foundation of Tianjin University.

更新日期/Last Update: 2018-04-10