|本期目录/Table of Contents|

 Smartphone-based cytometric biosensors for point-of-care cellular diagnostics(PDF)

《纳米技术与精密工程》[ISSN:1672-6030/CN:12-1351/O3]

期数:
2020年1期
页码:
32-42
栏目:
出版日期:
2020-03-15

文章信息/Info

Title:
 Smartphone-based cytometric biosensors for point-of-care cellular diagnostics
作者:
-
Author(s):
 Shengwei Zhang Zheng Li Qingshan Wei ?(魏青山)
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27606, United States
关键词:
-
Keywords:
Flow cytometry
Smartphone
Point-of-care diagnostics
Single-cell analysis
Imaging
Microfluidics
分类号:
-
DOI:
https://doi.org/10.1016/j.npe.2019.12.004
文献标识码:
A
摘要:
Abstract:
Analysis on a single-cell basis is both fundamental and meaningful in biomedical research and clinical practice.
Flow cytometry is one of the most popular approaches in this field with broad applications in cell sorting,
counting, and identification of rare cells. However, the complicated design and bulky size of conventional flow
cytometry have restricted their applications mainly in centralized laboratories. With the recent development
of smartphone devices, smartphone-based cytometry has been explored and tested for single-cell analysis. Compared
with traditional cytometers, smartphone-based cytometric biosensors are more suitable for point-of-care
(POC) uses, such as on-site disease diagnosis and personal health monitoring. In this review article, the history of
traditional flowcytometry is introduced, and advances of smartphone-enabled cytometry are summarized in detail
based on different working principles. Representative POC applications of smartphone cytometers are also
discussed. The achievements demonstrated so far illustrate the potential of smartphone-based cytometric devices
to transform single-cell measurement in general, with a significant impact in POC diagnostics, preventive
medicine, and cell biology.

参考文献/References

备注/Memo

备注/Memo:
更新日期/Last Update: 2020-04-30