|本期目录/Table of Contents|

 Recent advances in micro/nanoscale intracellular delivery(PDF)

《纳米技术与精密工程》[ISSN:1672-6030/CN:12-1351/O3]

期数:
2020年1期
页码:
18-31
栏目:
出版日期:
2020-03-15

文章信息/Info

Title:
 Recent advances in micro/nanoscale intracellular delivery
作者:
-
Author(s):
Mengjie Sun Xuexin Duan ?(段学欣)
 State Key Laboratory of Precision Measuring Technology & Instruments, Tianjin University, Tianjin, 300072, China
关键词:
-
Keywords:
Drug delivery
Physical approaches
Cell membrane disruption
Low dimension
分类号:
-
DOI:
https://doi.org/10.1016/j.npe.2019.12.003
文献标识码:
A
摘要:
Abstract:
Intracellular delivery enables the efficient drug delivery into various types of cells and has been a long-term studied
topics in modern biotechnology. Targeted delivery with improved delivery efficacy requires considerable requirements.
This process is a critical step in many cellular-level studies, such as cellular drug therapy, gene
editing delivery, and a series of biomedical research applications. The emergence of micro- and nanotechnology
has enabled themore accurate and dedicated intracellular delivery, and it is expected to be the next generation of
controlled delivery with unprecedented flexibility. This review focuses on several represented micro- and nanoscale
physical approaches for cell membrane disruption-based intracellular delivery and discusses the mechanisms,
advantages, and challenges of each approach. We believe that the deeper understanding of intracellular
delivery at such lowdimensionwould help the research community to develop more powerful delivery technologies
for biomedical applications.

参考文献/References

备注/Memo

备注/Memo:
更新日期/Last Update: 2020-04-30