|本期目录/Table of Contents|

 Noise in nanopore sensors: Sources, models, reduction, and benchmarking(PDF)

《纳米技术与精密工程》[ISSN:1672-6030/CN:12-1351/O3]

期数:
2020年1期
页码:
9-17
栏目:
出版日期:
2020-03-15

文章信息/Info

Title:
Noise in nanopore sensors: Sources, models, reduction,
and benchmarking
作者:
-
Author(s):
 Shengfa Liang ab Feibin Xiang ac Zifan Tang d Reza Nouri d Xiaodong He d Ming Dong d Weihua Guan(管伟华) de?
a Key Lab of Microelectronic Devices & Integrated Technology, Institute of Microelectronics, Chinese Academy of Sciences, Beijing 100029, China
b University of Chinese Academy of Sciences, Beijing 100049, China
c School of Electronic Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
d Department of Electrical Engineering, Pennsylvania State University, University Park, PA 16802, United States
关键词:
-
Keywords:
Noise
Nanopore
Model
Material
Noise reduction
分类号:
-
DOI:
https://doi.org/10.1016/j.npe.2019.12.008
文献标识码:
A
摘要:
Abstract:
 Label-free nanopore sensors have emerged as a new generation technology of DNA sequencing and have been
widely used for single molecule analysis. Since the first α-hemolysin biological nanopore, various types of
nanopores made of different materials have been under extensive development. Noise represents a common
challenge among all types of nanopore sensors. The nanopore noise can be decomposed into four components
in the frequency domain (1/f noise, white noise, dielectric noise, and amplifier noise). In this work, we reviewed
and summarized the physicalmodels, origins, and reduction methods for each of these noise components. For the
first time, we quantitatively benchmarked the root mean square (RMS) noise levels for different types of
nanopores, demonstrating a clear material-dependent RMS noise. We anticipate this review article will enhance
the understanding of nanopore sensor noises and provide an informative tutorial for developing future nanopore
sensors with a high signal-to-noise ratio.

参考文献/References

备注/Memo

备注/Memo:
更新日期/Last Update: 2020-04-30