|本期目录/Table of Contents|

 Insight into the effects of electrochemical factors on host-guest interaction induced signature events in a biological nanopore(PDF)

《纳米技术与精密工程》[ISSN:1672-6030/CN:12-1351/O3]

期数:
2020年1期
页码:
2
栏目:
出版日期:
2020-03-15

文章信息/Info

Title:
Insight into the effects of electrochemical factors on host-guest
interaction induced signature events in a biological nanopore
作者:
-
Author(s):
 XiaojunWei a; b;  Zehui Zhang a;  XiaoqinWang b;  Brian Lenhart b;  Roberto Gambarini a; 
Jonathan Gray a;  Chang Liu a; b; ?
a Biomedical Engineering Program, University of South Carolina, Columbia, SC 29208, USA
b Department of Chemical Engineering, University of South Carolina, Columbia, SC 29208, USA
关键词:
-
Keywords:
Nanopore
Host-guest interaction
Biosensors
Electrochemistry
分类号:
-
DOI:
https://doi.org/10.1016/j.npe.2019.12.001
文献标识码:
A
摘要:
Abstract:
The signature events caused by host-guest interactions in the nanopore system can be used as a novel and characteristic
signal in quantitative detection and analysis of various molecules. However, the effect of several electrochemical
factors on the host-guest interactions in nanopore still remains unknown. Here, we systematically
studied host-guest interactions, especially oscillation of DNA-azide adamantane@cucurbit[6] in α-Hemolysin
nanopore under varying pH, concentration of electrolytes and counterions (Li+, Na+, K+). Our results indicate
correlations between the change of pH and the duration of the oscillation signal. In addition, the asymmetric electrolyte
concentration and the charge of the counterions affects the frequency of signature events in oscillation
signals, and even the integrity of the protein nanopore. This study provides insight into the design of a future biosensing
platform based on signature oscillation signals of the host-guest interaction within a nanopore.

参考文献/References

备注/Memo

备注/Memo:
更新日期/Last Update: 2020-04-30