|本期目录/Table of Contents|

 1 000~2 500 nm宽波段的葡萄糖吸收光谱的测量波长优选(PDF)

《纳米技术与精密工程》[ISSN:1672-6030/CN:12-1351/O3]

期数:
2017年3期
页码:
199-204
栏目:
精密测量
出版日期:
2017-05-15

文章信息/Info

Title:
 Reasonable Selection of Wavelengths for Glucose Absorption
Spectrum from a Wide Waveband of 1 000—2 500 nm
文章编号:
1672-6030(2017)03-0199-06
作者:
 张紫杨 孙迪 刘冰洁 孙翠迎 刘瑾
 (精密测试技术及仪器国家重点实验室(天津大学),天津300072)
Author(s):
 Zhang Ziyang Sun Di Liu Bingjie Sun Cuiying Liu Jin
 (State Key Laboratory of Precision Measuring Technology and Instruments (Tianjin University), Tianjin 300072, China)
关键词:
 近红外光谱 葡萄糖测量 血糖 最佳光程长 波长优选
Keywords:
 near infrared (NIR) spectroscopy glucose measurement blood glucose optimum pathlength wavelength selection
分类号:
O433.1
DOI:
10.13494/j.npe.20160043
文献标识码:
A
摘要:
 采用近红外光谱法无创测量人体血糖时,葡萄糖浓度变化引起的光强信号微弱,为了实现目标测量精度,需要选择适宜的测量波长使葡萄糖引起的吸收信号水平强于噪声信号水平.本文提出了基于最佳光程长的测量波长选择原则,可在测量灵敏度最大的条件下,评价葡萄糖吸收光谱的测量是否可行.以葡萄糖在水溶液中的测量为例,基于最佳光程长理论,对1 000~2 500 nm的每个波长均进行光程优化,以1 mmol/L的检测浓度为目标,筛选了可行的测量波段.结果表明,即使在最佳光程长下检测,该检测目标对测量光谱的重复性信噪比要求也非常高,当SNR达到10 000∶1时,仅有4个波段满足要求,分别是:1 000~1 160 nm,1 375~1 420 nm,1 590~1 640 nm和 1 870~1 910 nm.其中短波长波段1 000~1 160 nm对光谱信噪比的要求最低,且最佳光程长最长,皮肤穿透深度最大,显示了较好的应用前景.这一结果对皮肤中的葡萄糖测量的波长选择有较好的参考价值.此外,本文所提出的波长选择方法也同样适用于采用吸收光谱法对其他物质成分的测量.
Abstract:
 In the blood glucose measurement based on near infrared (NIR) spectroscopy, high measurement precision could not be achieved easily because the optical signal caused by the glucose concentration variation in skin is relatively weak. The precision requirement can be satisfied only when the signals of glucose exceed the noises caused by the background during the test. We present an evaluation principle to reasonably select the available wavelengths from 1 000 nm to 2 500 nm, through which the signal of 1 mmol/L glucose concentration variation can be detected. In this evaluation, the used pathlength for every wavelength is optimized since the maximum measurement sensitivity can be acquired here. The evaluation principle was applied on the glucose measurement in water solution, and the available wavelength bands were found for the precision target of 1 mmol/L glucose concentration variation. The results show that the precision of 1 mmol/L requires a high signaltonoise ratio (SNR) for the recorded spectral data, even though the used wavelengths are the glucose absorption peaks and the optimum pathlengths are adopted for every wavelength. When the glucose signal of 1 mmol/L is compared with the noise, which is assumed to be 1/10 000 of the average signal amplitude, i.e. the SNR is 10 000∶1, it is found that only the signals from the wavebands of 1 000—1 160 nm,1 375—1 420 nm,1 590—1 640 nm and 1 870—1 910 nm can exceed the noise. Moreover, the waveband of 1 000—1 160 nm shows best performance on SNR requirement and skin penetration depth. This study could be useful to realize the precise glucose measurement in the media of skin as well as in water solution, and the evaluation principle on wavelength can also be applied in other components measurement based on the absorption spectroscopy.

参考文献/References

备注/Memo

备注/Memo:
收稿日期: 2017-03-21.
基金项目: 国家高技术研究发展计划(863计划)资助项目(2012AA022602,2012YQ090194);国家自然科学基金资助项目(60938002,81471698).
作者简介: 张紫杨(1989— ),女,硕士研究生.
通讯作者: 刘瑾,副教授,liu_jin@tju.edu.cn.
更新日期/Last Update: 2017-07-11