|本期目录/Table of Contents|

基于脑微结构信息检测的扩散峭度成像多b值组合优化(PDF)

《纳米技术与精密工程》[ISSN:1672-6030/CN:12-1351/O3]

期数:
2015年6期
页码:
414-419
栏目:
神经工程学中的精密测量、计算与控制技术
出版日期:
2015-11-15

文章信息/Info

Title:
Optimum b-Value Acquisition Schemes of Diffusion Kurtosis Imaging Based on Brain Microstructural Information Detection
作者:
沙 淼1 陈元园1 倪红艳2 王伟伟1 赵 欣1
1.天津大学精密仪器与光电子工程学院,天津300072; 2.天津市第一中心医院放射科,天津300192
Author(s):
Sha Miao1 Chen Yuanyuan1 Ni Hongyan2 Wang Weiwei1 Zhao Xin1
1. School of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, China; 2. Department of Radiology, Tianjin First Center Hospital, Tianjin 300192, China
关键词:
扩散峭度成像 扩散敏感因子b值 组织微结构
Keywords:
diffusion kurtosis imaging diffusion weighted factor b-value tissue microstructure
分类号:
R318
DOI:
10.13494/j.npe. 20150043
文献标识码:
A
摘要:
扩散峭度成像(DKI)引入高阶峭度张量来量化水分子扩散的非高斯程度,并可采用多种扩散敏感因子b值参与模型拟合,能反映组织复杂结构更微小变化,因而在脑神经科学研究与临床诊断中具有独特优势.但目前尚缺乏不同b值组合DKI数据采集对不同脑微结构特征的比较分析和针对不同临床需求制定DKI数据采集的最优b值组合方案的思路.本文从脑脊液、灰质和白质的DKI图像对比度角度,结合基于体素统计分析方法比较了5个不同b值组合与高、低2个b值组合采集方案对DKI成像指标的影响及在胼胝体局部组织微结构特征表达的差异.结果表明,低b值(<1 000 s/mm2)和高b值(>2 000 s/mm2)采集成像皆有较强的组织分辨能力,而过多增加b值组合个数会增大拟合误差并增加采集时间;使用高、低2个b值(2 000 s/mm2与1 000 s/mm2)的组合采集方案较适合于一般DKI临床诊断.
Abstract:
Diffusion kurtosis imaging (DKI), introducing a higher-order kurtosis tensor to quantify the non-Gaussian property of water diffusion as well as multiple diffusion weighted factor b-values to model fitting, is a powerful probe for assessment of the microstructure of biological tissues, enjoying a unique advantage in neuroscience and clinic diagnosis. However, there is still a lack of comparative analysis on different features of microstructure of brain using different b-value combinations in DKI data acquisition and thoughts of optimizing b-value combinations of DKI data acquisition according to different clinical needs. In this paper, DKI image contrast of cerebrospinal fluid, gray matter and white matter and voxel-based analysis of the whole brain were used to compare the influence of DKI parameter under 5 b-values scheme and 2 b-values scheme and the differences of corpus callosum local tissue microstructure characteristic expression. Results show that the combination of low b-value (<1 000 s/mm2) and high b-value (>2 000 s/mm2) DKI scheme has great resolution ability for tissues, while more b-values collected at the same time increase the acquisition time and the model fitting error as well; 2 b-values scheme ( 1 000 s/mm2, 2 000 s/mm2) will be more suitable for general DKI clinical diagnosis.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期: 2015-06-22. 基金项目: 国家自然科学基金资助项目 (81222021,31271062,61172008,81171423,51007063);国家科技支撑计划资助项目(2012BAI34B02);教育部新世纪优秀人才支持计划资助项目(NCET-10-0618);天津市自然科学基金青年基金资助项目(13JCQNJC14400). 作者简介: 沙 淼(1992— ),女,硕士生. 通讯作者: 赵 欣,讲师, zhaoxin@tju.edu.cn.
更新日期/Last Update: 2016-01-18